Mad1l1 ELISA Kit for Mouse(Mus musculus) | EIAab.comMad1l1 ELISA Kit for Mouse(Mus musculus)

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Mad1l1 (Gene name),

Mitotic spindle assembly checkpoint protein MAD1 (Protein name ), MD1L1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Mad1l1(Mad1);

Protein name:

Mitotic spindle assembly checkpoint protein MAD1;

Alternative:

Mitotic arrest deficient 1-like protein 1(MAD1-like protein 1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex. Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1. CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20. Also able to interact with the BUB1/BUB3 complex (By similarity). Interacts with TPR and NEK2.

Function:

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

Subcellular Location:

Nucleus Chromosome centromere kinetochore Cytoplasm cytoskeleton centrosome From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Co-localizes with NEK2 at the kinetochore.

Protein Attributes:

Sequence length:

717

Sequence:

50:

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300:

350:

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650:

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717:

AFLSALTIEL | FSRQTSI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000031534

String:

Q9WTX8

UniGene:

Mm.27250

SMR:

Q9WTX8

KEGG:

mmu:17120

Pfam:

PF05557

Uniprot:

Q9WTX8

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ELISA Kit for Mouse Mitotic spindle assembly checkpoint protein MAD1

Cat.:

E5695h

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Packing:

96T

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ELISA Kit for Mouse Mitotic spindle assembly checkpoint protein MAD1

Cat.:

E5695m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Mitotic spindle assembly checkpoint protein MAD1

Cat.:

U5695h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Mitotic spindle assembly checkpoint protein MAD1

Cat.:

U5695m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Mitotic spindle assembly checkpoint protein MAD1

Cat.:

P5695Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Mitotic spindle assembly checkpoint protein MAD1

Cat.:

P5695Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Mitotic spindle assembly checkpoint protein MAD1

Protein for Mouse Mitotic spindle assembly checkpoint protein MAD1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5."
Jin D.-Y. , Kozak C.A. , Pangilinan F. , Spencer F. , Green E.D. , Jeang K.-T.
Genomics55:363-364(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: FVB/N.
tissue: Mammary tumor.

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